Cellectis

    [td_text_with_title custom_title=”Company description”]Cellectis is a preclinical stage biopharmaceutical company focused on developing immunotherapies based on gene edited engineered CAR-T cells (UCART). The company’s mission is to develop a new generation of cancer therapies based on engineered T-cells. Cellectis capitalizes on its 15 years of expertise in genome engineering – based on its flagship TALEN® products and meganucleases and pioneering electroporation PulseAgile technology – to create a new generation of immunotherapies. CAR technologies are designed to target surface antigens expressed on cells. Using its life-science-focused, pioneering genome-engineering technologies, Cellectis’ goal is to create innovative products in multiple fields and with various target markets. Cellectis S.A. is listed on the Nasdaq Global Market (ticker: CLLS) and on the NYSE Alternext market (ticker: ALCLS).

    TALEN® is a registered trademark owned by Cellectis Group.[/td_text_with_title]

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    [/td_text_with_title][td_text_with_title custom_title=”From Wikipedia”]

    Cellectis is a French biopharmaceutical company. It develops genome-edited chimeric antigen receptor T-cell technologies for cancer immunotherapy.[1] It has offices in Paris and New York City.

    History

    Cellectis was founded by André Choulika in 1999.[2] It built up a successful business based on the use of meganucleases in genome engineering. Cellectis went public in 2007, and raised €21.2 million in a stock offering on EuroNext. In 2010 it acquired Cyto Pulse, which had developed a new electroporation technology,[3] and in 2011 it paid €28 million for Cellartis, a Swedish biotechnology company.[2] In January 2011 the company licensed TALEN gene-editing technology from Iowa State University and the University of Minnesota.[4][5]The company employed nearly 300 people.[2]

    With the advent of the CRISPR (clustered regularly interspaced short palindromic repeat) genome editing technique, the Cellectis meganuclease technology became uneconomic, and by 2013 the company was close to bankruptcy. It restructured, closed laboratories and reduced staff, and shifted research emphasis toward CAR-T technologies for cancer immunotherapy. Early in 2014 it reached a substantial financing deal with Servier, and later in the same year made a much larger agreement with Pfizer.[2]

    In March 2015 the company raised US$228 million through a stock offering on NASDAQ. The shares fell by 15% in the first week of trading.[6]

    Calyxt

    Cellectis formed the subsidiary of Calyxt in 2010[7] to develop gene editing techniques for the improvement of food. Based in New Brighton, Minnesota, the subsidiary filed for an IPO in June, 2017.[8] The work Calyxt does differs from genetically modified organisms, known as GMOs. Calyxt uses gene editing techniques such as talen to change the genome. In the case of Calyxt soybeans, two genes were turned off to create soybeans with a healthier mix of fatty acids.[9]

    CAR-T cancer treatment

    Cellectis is developing an “off-the-shelf” biopharmaceutical meant to work for any person who has a specific type of leukemia.[10]

    Most CAR-T therapies under development as of 2017 involved taking T-cells from the person with cancer and applying gene therapy to those cells to activate them to attack the person's cancer; an autologous cell therapy approach. Cellectis' approach starts with T-cells taken from healthy donors (allograft) and modifying these base cells with gene editing to disable the gene that causes donor immune cells to attack their host (preventing graft vs host disease). The base cells can then be modified the same way other CAR-T therapeutics are.[11]

    In early September 2017, the FDA suspended Cellectis’ Phase I trials in the wake of the death of a patient from cytokine release syndrome (CRS).[12]

    References

    1. ^ Bryce Elder, Arash Massoud, Andrew Ward, David Crow (28 May 2015). Biotech Cellectis in takeover talks with Pfizer. Financial Times. Accessed March 2016. (subscription required).
    2. ^ a b c d Philip Hemme (15 July 2015). "How Servier saved Cellectis, the French CAR-T Miracle". Labiotech.eu. Retrieved 16 March 2016. 
    3. ^ "Genetic Engineering & Biotechnology News - Biotech from Bench to Business". Genengnews.com. 8 November 2013. Archived from the original on 22 March 2016. Retrieved 16 March 2016. 
    4. ^ Marx, V (November 2012). "Genome-editing tools storm ahead". Nature Methods. 9 (11): 1055–9. doi:10.1038/nmeth.2220. PMID 23132115. 
    5. ^ "Cellectis Nabs TAL Effector IP from Minnesota and Iowa State Universities". GEN. January 20, 2011. 
    6. ^ "US IPO Weekly Recap: SolarEdge shines while other IPOs fall flat". NASDAQ.com. 27 March 2015. Retrieved 18 September 2017. 
    7. ^ Rehkamp, Patrick (21 July 2017). "Biotech firm Calyxt goes public, shares climb 30 percent". www.bizjournals.com. Retrieved 2017-10-08. 
    8. ^ "Agricultural biotechnology company Calyxt files for IPO". Star Tribune. Retrieved 2017-10-26. 
    9. ^ Chang, Kenneth (2017). "These Foods Aren't Genetically Modified but They Are 'Edited'". The New York Times. ISSN 0362-4331. Retrieved 2017-10-08. 
    10. ^ Weintraub, Karen. "Powerful Childhood Cancer Treatment Holds Promise--and Poses Hazards". Scientific American. Retrieved 2017-10-08. 
    11. ^ "Gene editing has saved the lives of two children with leukaemia". New Scientist. Retrieved 2017-10-08. 
    12. ^ McKee, Selina (2017-09-05). "FDA holds trials of Cellectis' cell therapy after patient death". www.pharmatimes.com. Retrieved 2017-10-08. 
    source: https://en.wikipedia.org/wiki/Cellectis[/td_text_with_title]