Alectinib (RG7853/AF-802/RO5424802/CH5424802) is an investigational oral medicine created at Chugai Kamakura Research Laboratories and is being developed for people with NSCLC whose tumours are identified as ALK+. ALK+ NSCLC is often found in younger people, women and those who have a light or non-smoking history. It is almost always found in people with a specific type of NSCLC, adenocarcinoma.
Early studies with alectinib have shown activity on brain metastases, indicating that the drug may be taken up in the brain. The brain is protected by the blood-brain barrier, a network of tightly joined cells that line the inside of the blood vessels in the brain and spinal cord. One of the ways the blood-brain barrier prevents molecules from affecting the brain is to actively eject them from the barrier through a process known as ‘active efflux.’ The active efflux system does not recognise alectinib, which means that it may travel into and throughout brain tissue.
The Global Phase 3 studies2 of alectinib include a companion test co-developed with Ventana Medical Systems, Inc., a member of the Roche Group. Alectinib will be marketed in Japan by Chugai Pharmaceutical, a member of the Roche Group.